SKF-96365 (hydrochloride)
1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-1H-imidazole hydrochloride
CAS: 130495-35-1
Molecular Formula: C22H27ClN2O3
SKF-96365 (hydrochloride) - Names and Identifiers
SKF-96365 (hydrochloride) - Physico-chemical Properties
| Molecular Formula | C22H27ClN2O3 |
| Molar Mass | 402.91 |
| Melting Point | 119 °C |
| Water Solubility | Soluble to 100mM in water |
| Solubility | Soluble in DMSO, not in water |
| Appearance | solid |
| Color | white |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| Use | SKF-96365 is a selective TRPC channel blocker. SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway. SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes. SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na(+) /Ca(2+) exchanger and increasing intracellular Ca(2+). SKF-96365 attenuates toxin-induced neuronal injury through opposite regulatory effects on Homer1a and Homer1b/c in cultured rat mesencephalic cells. |
| Target | TRP |
| In vitro study | SKF-96365 has anti-injury activity against MPP injury in PC12 cells, which can significantly inhibit apoptotic cell death after MPP application. SKF-96365 had no effect on the necrotic cell death induced by MPP. Because of the non-selective activity, SKF-96365 plays a lease on a variety of calcium ion channels: It not only inhibits high voltage activated calcium channels, but also effectively inhibits low voltage activated T-type calcium channels in HEK293 cells. SKF-96365 the specific effect on intracellular calcium homeostasis is determined by cell type and experimental model. |
| In vivo study | In in vitro and in vivo experiments, SKF-96365 treatment inhibited the calcium/calmodulin-dependent protein kinase II gamma (CaMKII gamma)/AKT signaling cascade. |
SKF-96365 (hydrochloride) - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | NI6823500 |
SKF-96365 (hydrochloride) - Reference
| Reference Show more | 1: Cheng H, Curtis AE, Fellingham C, Hancox JC. Multiple ion channel block by the cation channel inhibitor SKF-96365 in myocytes from the rabbit atrioventricular node. Physiol Rep. 2016 Jun;4(11). pii: e12819. doi: 10.14814/phy2.12819. PubMed PMID: 27288059. 2: Jing Z, Sui X, Yao J, Xie J, Jiang L, Zhou Y, Pan H, Han W. SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway. Cancer Lett. 2016 Mar 28;372(2):226-38. doi: 10.1016/j.canlet.2016.01.006. Epub 2016 Jan 20. PubMed PMID: 26803057. 3: Liu H, Yang L, Chen KH, Sun HY, Jin MW, Xiao GS, Wang Y, Li GR. SKF-96365 blocks human ether-à-go-go-related gene potassium channels stably expressed in HEK 293 cells. Pharmacol Res. 2016 Feb;104:61-9. doi: 10.1016/j.phrs.2015.12.012. Epub 2015 Dec 12. PubMed PMID: 26689773. 4: Bencze M, Behuliak M, Vavřínová A, Zicha J. Broad-range TRP channel inhibitors (2-APB, flufenamic acid, SKF-96365) affect differently contraction of resistance and conduit femoral arteries of rat. Eur J Pharmacol. 2015 Oct 15;765:533-40. doi: 10.1016/j.ejphar.2015.09.014. Epub 2015 Sep 16. PubMed PMID: 26384458. 5: Chen KH, Liu H, Yang L, Jin MW, Li GR. SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes. Pflugers Arch. 2015 Jun;467(6):1227-36. doi: 10.1007/s00424-014-1565-4. Epub 2014 Jul 15. PubMed PMID: 25017106. 6: Song M, Chen D, Yu SP. The TRPC channel blocker SKF 96365 inhibits glioblast |
SKF-96365 (hydrochloride) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.482 ml | 12.41 ml | 24.819 ml |
| 5 mM | 0.496 ml | 2.482 ml | 4.964 ml |
| 10 mM | 0.248 ml | 1.241 ml | 2.482 ml |
| 5 mM | 0.05 ml | 0.248 ml | 0.496 ml |
Last Update：2024-01-02 23:10:35
SKF-96365 (hydrochloride) - Cell Experiment
To investigate whether SKF-96365 could protect PC12 cells from injury induced by MPP+ insult, cultured PC12 cells are pretreated with SKF-96365 in different concentrations (1 µM, 10 µM or 50 µM) 30 min before MPP+ addition. The cells viability is measured 24 h after MPP+ insult by using the cell proliferation reagent WST-1. (Only for Reference) Cell lines: PC12 cells
Last Update：2023-08-16 21:32:38
SKF-96365 (hydrochloride) - Reference Information
| biological activity | SKF96365, originally considered to be a calcium channel blocker, is currently used as a TRPC channel blocker and is widely used in medical diagnosis. |
| target | TargetValue TRPC () |
| Target | Value |
| in vitro study | SKF-96365 has anti-damage activity to MPP injury in PC12 cells, and can significantly inhibit apoptotic cell death after MPP is applied. SKF-96365 has no effect on the necrotic cell death induced by MPP. Because of its non-selective activity, SKF-96365 lease a variety of calcium channels: it not only inhibits high-voltage activated calcium channels, but also effectively inhibits low-voltage activated T-type calcium channels in HEK293 cells. The specific effect of SKF-96365 on intracellular calcium homeostasis is determined by cell type and experimental model. |
| In vivo research | In in vitro experiments, SKF-96365 treatment can inhibit calcium/calmodulin-dependent protein kinase II γ(CaMKII γ)/AKT signal cascade reaction. |
Last Update：2024-04-10 22:29:15
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Product Name: SKF-96365 Visit Supplier Webpage Request for quotationCAS: 130495-35-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
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Product Name: SKF-96365 Visit Supplier Webpage Request for quotationCAS: 130495-35-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SKF-96365 (hydrochloride) Visit Supplier Webpage Request for quotationCAS: 130495-35-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: 1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-1H-imidazole hydrochloride Visit Supplier Webpage Request for quotation
CAS: 130495-35-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 130495-35-1
Tel: 18301782025
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View History
SKF-96365 (hydrochloride)
Asomate
[2-[(3-甲基丁基)氨基]-3-吡啶基][4-(苯基甲基)-1-哌嗪基]甲酮(NSI-189)
1-[2-(吗啉-4-基)乙基]吡咯烷-3-胺三盐酸盐
Hexahydro-4aH-[1,4]dioxino[2,3-c]pyrrole hydrochloride (1:1)
r-1-甲基萘甲胺溴
L-缬氨酰-N5-(氨基羰基)-N-[4-(羟甲基)苯基]-L-鸟氨酰胺
2-[(4-AMINO-5-METHOXY-2-METHYLPHENYL) SULFONYL] HYDROGENSULFATE ESTER
2-ETHYLVINYLPHOSPHONIC ACID
(4-羟甲基噻唑-2-基)氨基甲酸叔丁酯
Asomate
[2-[(3-甲基丁基)氨基]-3-吡啶基][4-(苯基甲基)-1-哌嗪基]甲酮(NSI-189)
1-[2-(吗啉-4-基)乙基]吡咯烷-3-胺三盐酸盐
Hexahydro-4aH-[1,4]dioxino[2,3-c]pyrrole hydrochloride (1:1)
r-1-甲基萘甲胺溴
L-缬氨酰-N5-(氨基羰基)-N-[4-(羟甲基)苯基]-L-鸟氨酰胺
2-[(4-AMINO-5-METHOXY-2-METHYLPHENYL) SULFONYL] HYDROGENSULFATE ESTER
2-ETHYLVINYLPHOSPHONIC ACID
(4-羟甲基噻唑-2-基)氨基甲酸叔丁酯